Gamboa introduced him to his manager, Jhun Reyes, who brought him to ABS-CBN for the first season of Pinoy Big Brother: Teen Edition.
Anderson and the other housemates entered the Big Brother house on April 23, 2006.
In May 2008 Anderson and Chiu were cast in My Girl, an adaptation of the South Korean TV series.
In 2009, Anderson starred in the primetime drama series Tayong Dalawa, winning the Best Drama Actor award at the NSUU TV Awards; Anderson and Chiu were the Most Popular Loveteam for the third consecutive year at the Guillermo Mendoza Memorial Scholarship Foundation Box Office Awards.
He finished his elementary studies in San Antonio, Texas, and completed high school in General Santos City, Philippines.
Anderson was discovered by Joross Gamboa when Gamboa performed in Anderson's hometown.
Rachelle Ann "Shin" Villalobos Go-Spies (born August 31, 1986) is a Filipino singer and international musical theater actress.
Six months later, Anderson and screen partner/then-girlfriend, actress Kim Chiu, appeared together on several ABS-CBN shows (including Love Spell and Aalog-Alog) and in the film First Day High.In August of that year, he appeared in Agimat: Ang Mga Alamat ni Ramon Revilla: Tiagong Akyat.The following year, Anderson started with Kim Chiu in the film Paano Na Kaya.He is best known for his lead roles in TV series such as Sana Maulit Muli (2007), My Girl (2008), action dramas, Tayong Dalawa (2009) in which he plays a soldier, and an NBI Agent in Kung Tayo'y Magkakalayo (2010), a mentally challenged young man in Budoy (2011–2012), in the TV adaptation of the iconic comics character "Fredo" in Mars Ravelo's Dyesebel (2014), the Fantasy drama, Nathaniel (2015) and in the Cannes Film Festival Director's Fortnight entry On The Job (2013).Anderson won his first ever Best Actor trophy courtesy of the 24th PMPC Star Awards for Television for an episode of Maalaala Mo Kaya wherein he played a person stricken with Tourette Syndrome.